Fast forward to this week and the same subject was brought up at Owl Tree Studio, referencing a free 'Size for Web' action available at Oscraps. The action includes a step for sharpening layouts as well.
Well, this was enough to get me to actually try it and see what happens. I have to say, I was a bit surprised! I had never felt my layouts were 'fuzzy' in the past, but seeing the before and after has now convinced me to include this step in my workflow.
For this layout, I used Filter>Sharpen>Unsharp Mask with settings of Amount - 85%, Radius - 1.0 and Threshold - 4 (as suggested by Aaron). You can click on the image to see it even larger. Check out the overall clarity difference, especially in the journaling and title.
"Cool Chick" digital scrapbook layout by Christy VanderWall uses: